{"product_id":"igf-1-lr3-upa","title":"IGF-1 LR3 UPA","description":"\u003cp\u003e\u003ca href=\"https:\/\/en.wikipedia.org\/wiki\/Insulin-like_growth_factor_1\" rel=\"noopener\" target=\"_blank\"\u003eIGF-1 LR3\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eis a hormone that functions as the major mediator of growth hormone \u003cspan\u003e \u003c\/span\u003e(GH)-stimulated somatic growth, as well as a mediator of GH-independent anabolic responses in many cells and tissues. Insulin-like Growth Factor-1 is a small peptide (molecular weight 7647) that circulates in serum bound to high affinity binding proteins. It is an unusual peptide in this regard since it is more than 99 percent protein-bound.\u003c\/p\u003e\n\u003ch4\u003eIt is synthesized by multiple mesenchymal cell types. As a result, there are two major mechanisms of IGF-1 regulation:\u003c\/h4\u003e\n\u003cp\u003e●IGF-1 that is synthesized in the liver and secreted into the blood is under the control of GH.\u003c\/p\u003e\n\u003cp\u003e●Autocrine\/paracrine IGF-1 is\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003esynthesized in peripheral tissues\u003c\/strong\u003e, such as bone. Its synthesis is controlled by GH and by factors that are secreted locally by the surrounding cell types. Some of the secreted autocrine\/paracrine IGF-1 enters the systemic circulation. Therefore, understanding the regulation of autocrine\/paracrine synthesis of this peptide is necessary to interpret changes in serum IGF-1 concentrations.\u003c\/p\u003e\n\u003cp\u003eInsulin-like Growth Factor-1 exerts its effects via activation of the\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eInsulin-like Growth Factor-1 receptor\u003c\/strong\u003e. This receptor is widely distributed, which enables blood-transported IGF-1 to coordinate balanced growth among multiple tissues and organs. In contrast, autocrine\/paracrine Insulin-like Growth Factor-1 can stimulate local, unbalanced growth independently of systemic GH. Examples of this type of growth regulation are wound healing and growth of the contralateral kidney after unilateral nephrectomy.\u003c\/p\u003e\n\u003ch2\u003eAdditional information\u003c\/h2\u003e\n\u003ctable class=\"woocommerce-product-attributes shop_attributes\"\u003e\n\u003ctbody\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_chemical-composition\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eChemical Composition\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eInsulin Growth Like Factor\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_strength\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eStrength\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003e100mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_pack-size\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003ePack Size\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003e1 Vial\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr class=\"woocommerce-product-attributes-item woocommerce-product-attributes-item--attribute_pa_laboratory\"\u003e\n\u003cth class=\"woocommerce-product-attributes-item__label\"\u003eLaboratory\u003c\/th\u003e\n\u003ctd class=\"woocommerce-product-attributes-item__value\"\u003e\n\u003cp\u003eU.P.A.\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2 class=\"yikes-custom-woo-tab-title yikes-custom-woo-tab-title-dosage-instructions\"\u003eDosage Instructions\u003c\/h2\u003e\n\u003cp\u003eInjected via Subcutaneous injection after a workout at 20 – 40mcg per day with a typical cycle length of 4-6 weeks\u003c\/p\u003e","brand":"Peak Anabolic","offers":[{"title":"Default Title","offer_id":48849229480088,"sku":null,"price":350.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0761\/7576\/9752\/files\/IGF-1-LR3-UPA.png?v=1775469095","url":"https:\/\/peakanabolczone.co.za\/products\/igf-1-lr3-upa","provider":"Peak Anabolic Zone","version":"1.0","type":"link"}